Tel. 380 44-483-35-92
How to find: Institute of Neurosurgery, Building 1, 7th floor (see Map and Institute scheme).
The main directions of scientific research of the department of neurobiochemistry
Study of genetic susceptibility to degenerative processes in the intervertebral disc based on genotyping of collagen genes: COL1A1 (rs1800012), COL2A1 (rs2276454), COL2A1 (rs1793953), COL9A (rs1135056), COL11A1 (rs1676486) and collagen receptor gene VDR (rs2228570).
Investigation of the properties of platelets to enhance chemotaxis of neuronal cells, platelet-enriched 3D fibrin-based matrix, regenerative properties of platelet-rich plasma with the aim of improving therapy for CNS and peripheral nervous system injuries.
Typing of glial tumors by IDH polymorphism to predict disease severity, predict survival, and optimize therapy.
Study of mutations in the EGFR gene and PTEN expression to justify the appointment of targets – oriented therapy.
Study of MGMT gene expression and substantiation of optimal regimens of glioma chemotherapy with temozolamide.
Study of the expression of metalloproteinases MMP2 and MMP9 for the prediction of tumor cell migration.
Study of MDR, MRP, LRP, GSTP gene expression; genotyping of GSTT, GSTM, for the prediction of chemoresistance in order to optimize the selection of chemotherapy drugs.
Study of the expression of the CD133 gene for the typing of glial tumors by the number of stem tumor cells, which allows for an objective assessment of the degree of malignancy of neurotumors.
Research of neurotropic viruses using amplification methods (EBV, CMV, HSV ½, VZV, HHV-8, HHV-6, HHV-7, JCV, BKV, SV-40, HTLV, MV, HuCoV) (differential diagnosis of glial tumors and focal encephalitis, diagnosis of virological neuralgia of the trigeminal nerve).
Study of genetic susceptibility to ischemic and hemorrhagic stroke based on genotyping results of MTHFR (C677T), MTHFR (A1298T,) MTRR (A66G), eNOS (4a/4b), eNOS (G894T), eNOS(T786 C), prothrombin (G20210A), FV ( –G1691A), β-fibrinogen (C148T), AGT (M235T), AGT (T174M), ACE (ID polymorphism), MTR (A2756G). Study of restorative potential after stroke based on CD105 gene expression results.
Updated 30 August 2022
Content management: Anna Nikiforova
Content management: Tetyana Yovenko